| abstract |
A chidamide pharmaceutical composition, a preparation method therefor and an application thereof. The pharmaceutical composition comprises chidamide and a medicinal enteric-coated excipient that serves as a carrier. In the composition, chidamide is used as a guest molecule, and the medicinal enteric-coated excipient is a carrier molecule. Oral pharmacokinetic testing on animals proves that the bioavailability of the composition containing chidamide and the medicinal enteric-coated excipient is greatly improved, while adverse reactions caused by a drug in the gastrointestinal tract are reduced; in addition, the dosage may be reduced while maintaining the curative effect, thus having more important clinical significance than commercially available chidamide tablets. |