abstract |
A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite selected from aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI) and N-acetylputrescinium (NAP) below an inhibitory concentration in the cell culture medium for the at least one metabolite. |