| abstract |
The present invention describes the development of a modified envelope glycoproteins to pseudo-type viruses of the retroviridae family. These are derived from Murine leukaemiavirus amphotropic, Gibbon Ape leukaemia virus and feline endogenous virus envelopes. The improved envelope glycoproteins contain, among other modifications, newly introduced alternative cleavable sequences. The viral vectors pseudo-typed with these modified envelopes may be suitably employed for cargo delivery such as in gene and cell therapy applications, for the ex vivo and in vivo delivery of gene(s), protein(s), or molecule(s) of interest to a variety of target cells. |