| abstract |
The present invention provides a compound having a structure as represented by formula I or a pharmaceutically acceptable salt thereof, wherein R1 is selected from hydrogen, fluorine, and chlorine; R2 and R3 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, and aryl, or R2 and R3 are connected to form a ring which may be cycloalkyl, substituted cycloalkyl, aromatic heterocycle, or non-aromatic heterocycle; R4 is selected from hydrogen, cyano, alkyl, substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, and aryl; and R5 is selected from hydrogen, halogen, and halogenated alkyl. The present invention further provides a pharmaceutical composition comprising the compound. The compound and composition of the present invention show significant activity in treating prostate cancer. |