| abstract |
The present disclosure relates to medical devices such as syringes, auto- injectors, and pens that inhibit oxygen permeation into the fluid chamber. The medical device includes a lubricant-free (e.g., silicone) or a siliconized barrel having an interior surface defining a fluid chamber, an elastomeric stopper, and a plunger rod. In one embodiment, at least a portion of the interior surface of the barrel is reduced to increase the interference fit between the stopper and the barrel. In another embodiment, the stopper may include a plurality of ribs and a valley between each pair of ribs may include a ring member provided in each of the valleys. The ring member includes an oxygen-absorbing, an oxygen-adsorbing material, or both, to bind any oxygen that permeates into the syringe, auto-injector, or pen. In yet another embodiment, the stopper may include a barrier coating including an oxygen barrier material to inhibit or prevent oxygen permeation. |