| abstract |
The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least: - a basal insulin whose isoelectric point pl is between 5.8 and 8.5; - A co-polyamino acid consisting of glutamic or aspartic units as defined in the claims. In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid carrying carboxylate charges and at least one hydrophobic radical -Hy is chosen from the co-polyamino acids of formula (XXXb) in which: D independently represents either a -CH2 - group (aspartic unit) or a -CH2-CH2 group - (glutamic unit); X represents a cationic entity chosen from the group comprising alkaline cations; Rb and Rb ′, which may be identical or different, are either a hydrophobic radical -Hy, or a radical chosen from the group consisting of an H, a linear C2 to C10 acyl group, a branched C3 to C10 acyl group, a benzyl, a terminal "amino acid" unit and a pyroglutamate, at least one of Rb and R'b is a hydrophobic radical -Hy; Q and Hy have the meanings given above; n + m represents the degree of polymerization DP of the co-polyamino acid, that is to say the average number of monomeric units per chain of co-polyamino acid and 5 = :; n + m = :; 250. |