| abstract |
ABSTRACT The present invention discloses novel BRaf inhibitors, compositions containing these inhibitors and uses thereof for the treatment, amelioration and/or prevention of cutaneous reactions, wherein the inhibitors are compounds of formula (I): H N ( N NI I N' NHR (I) or a pharmaceutically acceptable salt or a solvate thereof, wherein R is 3-chloro-4-fluorophenyl, 2-fluoro-4-iodophenyl, 4-chloro-3-(trifluoromethyl)phenyl, 3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl, or 3-(trifluoromethoxy)phenyl. Date Recue/Date Received 2021-02-05 |