| abstract |
CA 3060687 Abstract This invention provides an attenuated mutant dengue (DEN) virus comprising a C to U nucleotide substitution at nucleotide position 7129 based upon the prototypic isolate DEN4 Dominica 1981, wherein the attenuated mutant DEN virus has at least one of reduced plaque formation size, host-cell restriction in mosquito cells, and improved replication in Vero cells, and use of such a virus in producing neutralizing antibodies against dengue virus. Date Recue/Date Received 2020-06-01 |