| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f732716d47d2ca82d4ded7a8860aac7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1114
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate |
2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17941bd3440f64444abab230d05184ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6b20aac7286309990ef0b41de1b4137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_080b3dfd253a55f6e0bb066fe1b3bcce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db9e2756a22bc111bb9d73bf7e1c008d |
| publicationDate |
2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-3046351-A1 |
| titleOfInvention |
Three-dimensional in vitro alveolar lung model, process for preparing said model, and its use for determining and /or predicting the sensitizing effects of inhalable products |
| abstract |
The invention relates to a three-dimensional in vitro alveolar lung model comprising essentially the four cells types as follows: alveolar type II epithelial cells able to secrete (lung laying ) surfactant, endothelial cells which forms the inner lining of capillaries providing a permeable barrier, dendritic-like cells, such as non-differentiated THP-1, linking innate and adaptive immunity and macrophage-like cells, able to participate to defense mechanisms by ingesting foreign materials by phagocytosis. The invention also relates to a process for preparing said model, and its use for assessing the irritation potential or toxicity of inhalable products such as particles or molecules on the alveolar barrier of lungs, and also for determining and/or predicting the sensitizing effects of inhalable products such as particles or molecules on the alveolar barrier of lungs. |
| priorityDate |
2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |