| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f8f7b187eef12b316baeb5e34d62755 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198 |
| filingDate |
2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22692c3d29cde5847fddfc7c7f007b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21bf1ecf973109a6eeb3770983a4bd03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1eb52fdb089c0b804438b5c52db4f71 |
| publicationDate |
2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-3044137-C |
| titleOfInvention |
Improved synthesis of lysine acetylsalicylate · glycine particles |
| abstract |
The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate · glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providing an aqueous solution of lysine; c) combining the solutions of step a) and b) to form a mixture; d) optionally stirring the mixture; e) adding acetone to the mixture; f) incubating the mixture, to allow the formation of a acetylsalicylic acid lysinate product; g) isolating the acetylsalicylic acid lysinate product; wherein acetylsalicylic acid is used in excess compared to lysine and wherein no seed crystals are added to the mixture; and optionally the following further steps: h) providing a recrystallized glycine; wherein the glycine has been recrystallized with the following steps: h1) dissolving glycine in water; h2) adding acetone to the glycine solution; h3) stirring the mixture until a precipitate is obtained; i) combining the recrystallized glycine of step h) with the acetylsalicylic acid lysinate product of step g) to obtain lysine acetylsalicylate · glycine (LASAG) particles. |
| priorityDate |
2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |