http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-3044102-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56618388f2328e749c6940f048b40210 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13d5a99d29fb7630b038eb664d216091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_448bac1e68bee724702ab3b45b22a7c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46dcb73762493423f26f86fbbd8701b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b0c9c6e88c9f1466cf50b38830ef385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0c6ef14528acfd81cbb871cc904282c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f68188fb533983be44782739a2ebcbf |
| publicationDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-3044102-C |
| titleOfInvention | Precursors for radiofluorination |
| abstract | The invention relates to a method for producing a radiofluorinated compound, which has an aromatic or heteroaromatic ring, which carries [18F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, as well as a spacer group, which connects the aromatic or heteroaromatic ring to the bonding unit, wherein the bonding unit carries at least one second substituent selected from the group consisting of -OH, -CONH, and -COOH, wherein the bonding unit is connected to the spacer group via a bond A1 and the spacer group is connected to the aromatic or heteroaromatic ring via a bond A2. It is provided that the method comprises the steps of: (a) providing a precursor, which has the aromatic or heteroaromatic ring, which carries a substituent Y, the bonding unit, which can bind to the peptide or peptide mimetic and carries at least one second substituent, as well as the spacer group, wherein substituent Y is selected from the group consisting of -1\1+(R1R2R3), -NO2, -C1, -Br, -F, or -I, and R1, R2, and R3 are the same or different from each other and each are unsubstituted or substituted C1-C6 alkyl; and (b) reacting the precursor with a [18F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, wherein the substituent Y is replaced by [18F] fluoride, and wherein the activation salt has a cation of the general formula N1-(R4R5R6R7), wherein R4, R5, R6, and R7 are the same or different from each other and each are unsubstituted or substituted C1-C6 alkyl. |
| priorityDate | 2016-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.