http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-3044102-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56618388f2328e749c6940f048b40210 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13d5a99d29fb7630b038eb664d216091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0c6ef14528acfd81cbb871cc904282c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46dcb73762493423f26f86fbbd8701b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b0c9c6e88c9f1466cf50b38830ef385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_448bac1e68bee724702ab3b45b22a7c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f68188fb533983be44782739a2ebcbf |
| publicationDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-3044102-A1 |
| titleOfInvention | Precursors for radiofluorination |
| abstract | The invention relates to a method for producing a radiofluorinated compound which has an aromatic or heteroaromatic ring which carries [18F] fluorine as the first substituent, a bonding unit which can bond to a peptide or a peptide mimetic, and a spacer group which connects the aromatic or heteroaromatic ring to the bonding unit, the bonding unit carrying at least one second substituent selected from the group consisting of -OH, -CONH and -COOH, the bonding unit being connected to the spacer group via a bond A1, and the spacer group being connected to the aromatic or heteroaromatic ring via a bond A2. According to the invention, the method comprises the following steps: (a) providing a precursor which has the aromatic or heteroaromatic ring which carries a substituent Y, the bonding unit which can bond to the peptide or the peptide mimetic and carries the at least one second substituent, and the spacer group, wherein the substituent Y is selected from the group consisting of -N+(R1R2R3), -NO2, -Cl, -Br, -F or -I, and R1, R2 and R3 are identical to or different from one another and are each unsubstituted or substituted C1-C6 alkyl; and (b) reacting the precursor with an [18F] fluoride anion in the presence of an activation salt to produce the radiofluorinated compound, wherein the substituent Y is replaced by [18F] fluorine and wherein the activation salt has a cation of the general formula N+(R4R5R6R7), where R4, R5, R6 and R7 are identical to or different from one another and are each unsubstituted or substituted C1-C6 alkyl. |
| priorityDate | 2016-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.