| abstract |
The present invention relates to compounds represented by formula 1 below or a pharmaceutically acceptable salt thereof: wherein, n is an integer of 1 or 2; R1 is -C1 or -CH3; R2 is -H or -C1; R3 is -H, -F, -C1, -Br, methyl, ethyl, isopropyl, pentyl, hexyl, octyl, -OCH3, or, R3 and R4, with the from neighbouring 2 carbons on the phenyl, combine to form or ; and R4 is -H, -C1, -CH3 or -CF3. These compounds according to the present invention remarkably inhibits activity of DRAK that inhibits signal systems of TGF-.beta., which is known to suppress cancer growth, and thus the novel pyrimidine compounds can be used as a pharmaceutical composition for preventing or treating cancer and can be used as a pharmaceutical composition for preventing or treating inflammatory disease. |