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filingDate 2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-3009252-C
titleOfInvention Biodegradable amphiphilic polymer, polymeric vesicles prepared therefrom, and application of biodegradable amphiphilic polymer in preparation of medicines for targeted therapy of lung cancer
abstract Disclosed is a polymeric vesicle prepared by a biodegradable amphiphilic polymer, and the polymeric vesicle for use as a carrier of a drug for lung cancer treatment , wherein the chemical structure of the biodegradable amphiphilic polymer is one of the following structures: (see formula I) (see formula II) The biodegradable amphiphilic polymer is obtained by an activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing a functional group of dithiolane ring, which has a controllable molecular weight and a narrow molecular weight distribution; the polymer obtained by the ring-opening polymerization of the cyclic carbonate monomer of the present disclosure has biodegradability and can be used to control the drug release system, the prepared lung cancer-targeted reduction-sensitive reversibly-crosslinked polymeric vesicle as a nanomedicine carrier supports stable long circulation in vivo.
priorityDate 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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