| abstract |
Disclosed is a novel 1,3,4-oxadiazole amide derivative compound represented by the general formula I: (see formula I)> having histone deacetylase 6 (HDAC6) inhibitory activity, an optical isomer or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a treatment method using the composition, and a preparation method therefor. The novel compound, optical isomer thereof or pharmaceutically acceptable salts thereof have histone deacetylase 6 (HDAC6) inhibitory activity and are effective for the prevention or treatment of HDAC6-associated diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; psychological and behavioral disorders; neurological diseases; eye and adnexa diseases; circulatory system diseases; respiratory system diseases; digestive system diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; or congenital malformations, deformations and chromosomal abnormalities. |