| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3400916632f5d53b111ef504d361dfb1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-18 |
| filingDate |
2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98348125fd39b075b814d58cc70a44ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86cd8eceb1a12d7c21fe805e41029eb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0f6962eca0edea03e305f3974554fc |
| publicationDate |
2017-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2989364-A1 |
| titleOfInvention |
Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
| abstract |
The present invention relates an improved and well reproducible process for the preparation of Enclomiphene citrate having needle shaped crystal habit, and moreover, by using a mixture of a C2-05 alkyl alcohol and water, wherein the amount of water is comprised between 10% and 40% v/v, furthermore it is also related to a solid form of Enclomiphene citrate. The produced Enclomiphene citrate having needle shaped crystal habit, has a specific particle size distribution, is thermodynamically more stable, is more soluble in water neutral or at acid pH values and is in form of only needle crystals and is an homogeneous solid. These features allow to obtain a suitable product for pharmaceutical composition and for use in medicine. |
| priorityDate |
2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |