Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52c6178654aca28f53dca43e262f505c |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2795-14022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
filingDate |
2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dbaa799cd4d1a5bbd6d0cefbfe7a4d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f7a18ab363ce270b5eab7ab61bfa747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c001c1db2b907e78dc91ce3466fa886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c16819a60f3a5a3635f505e12d100030 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1c5aeae9ce0cb9bc03d94036de11f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebcec7a855963d1220dd934dea8fbc68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1acbad1c4c4f679673b7ca9b97762e8c |
publicationDate |
2016-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2969128-A1 |
titleOfInvention |
Polypeptides comprising a modified bacteriophage g3p amino acid sequence lacking a glycosylation signal |
abstract |
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid deletion, insertion or substitution to remove a putative glycosylation signal. The invention further relates to such polypeptides that are also modified through additional amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability to bind and/or disaggregate amyloid. The invention further relates to the use of these g3p-modified polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid. |
priorityDate |
2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |