http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2967876-A1

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1224e3c07b7cc5684ee81d9e1e5ee15c
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-18
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
filingDate 2015-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afdcd12810182d10c345c5272db8a219
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9eae79b56033b7fd8191203780a63c9
publicationDate 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2967876-A1
titleOfInvention Formulations comprising a meglumine salt of the metal complex gd-dota
abstract The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA as a meglumine salt, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation ofMRI contrast agents based on Gd-DOTA.
priorityDate 2014-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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