| abstract |
The invention relates to novel (R)-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1, or spiro analogues thereof, which exhibit androgen receptor antagonist properties, variants of a method for producing same, and intermediate compounds for producing compounds of formula 1. Compounds of formula 1 can be used to produce a medicinal agent suitable for treating cancers, such as prostate cancer and breast cancer. The invention also relates to a pharmaceutical composition in the form of tablets, capsules and injections. In formula 1, R1 is OH, NH2 or an OR4 group; R2 and R3 are methyl, or R2 and R3 are a ??2-??2 group; and R4 is ?1-?4 alkyl or cyclopropyl. |