abstract |
The invention relates to novel isoquinoline derivatives of formula (I), their synthesis and their use in the prevention and / or treatment of pathologies that result from the activation of the RhoA / ROCK pathway and the phosphorylation of the light chain. myosin. X represents a -C (= O) -, -CH (OH) - or -CH2- group, and the other substituents represent various groups as defined in claim 1. |