http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2934850-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-2208 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-22 |
| filingDate | 2014-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d41825e7f78d792979da2ded7768daed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02c6245329576265c1e6ef7a3066bc04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86146b0bc371459f4a2e9f0e0e79b87b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9131374855ec78d53b111deaa0dab41 |
| publicationDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2934850-C |
| titleOfInvention | Methods and reagents for radiolabeling |
| abstract | Provided are radiolabelled compounds of Formula l and methods for synthesis of such radiolabelled compounds directed to improving yields and reducing loss of radioisotopes: wherein: X is ¨CH2-, -0-, or ¨S-; Y1 and Y2 are independently ¨CR3a- or ¨N-;Z1, Z2, and Z3 are independently ¨CH- or ¨N-; R1 is hydrogen or halogen; L is a straight or branched, C2_14 aliphatic group wherein one or more carbons are optionally and independently replaced by ¨NR-, wherein R is other than a ¨Boc protecting group; R2 is hydrogen or an optionally substituted group as described herein; or ¨L-R2 is selected as described herein, and wherein ¨L-R2 does not contain a Boc-protected secondary amine; each R3 or two R3 groups is as described herein; R3a is R3 or hydrogen; R4 is C1_4 alkyl; and each R is independently hydrogen or an optionally substituted group as described herein, or two R groups on the same nitrogen are taken together with their intervening atoms to form an optionally substituted ring as described herein. Radiolabelled compounds, such as radiolabelled Hsp90 inhibitors, are clinically useful in treatment regimens, patient diagnoses and patient monitoring applications. |
| priorityDate | 2013-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 217.