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publicationDate 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2934231-C
titleOfInvention Method for preparing hydroxypropyl methylcellulose acetate succinate (hpmcas) grains having controlled grain size distribution, and hpmcas powder
abstract Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step (esterification step) of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS; and a step (granulating step) of putting the reaction solution into water continuously or intermittently so as to form grains.
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