Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd15fea28fa5c3272dd3e41dcf3b0dd3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3525 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 |
filingDate |
2014-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa81fbfee8f42f3abf3ee48567f2525d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe6ff774281227b6302928ce074513d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c8c0fd0bf9ca7b6ba9a8a2f57a57a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad3e4bcfd55bb83c20cf4b13ecda7a3f |
publicationDate |
2015-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2917318-A1 |
titleOfInvention |
Dengue virus related genes-specific sirna, double-stranded oligo rna molecules comprising the sirna, and composition for the inhibition of dengue virus replication comprising the same |
abstract |
The present invention relates to a dengue virus-specific siRNA, a high-efficiency double helix oligo-RNA structure comprising the siRNA, and a composition for suppressing the proliferation of dengue virus comprising the RNA structure. The double helix oligo-RNA structure has a structure in which a hydrophilic material and a hydrophobic material are grafted on both ends of a double helix RNA (siRNA) via a simple covalent bond or a linker-mediated covalent bond so that the double helix oligo-RNA structure is efficiently delivered into cells, and can be transformed into a nanoparticle type by a hydrophobic interaction of the double helix RNA structures in an aqueous solution. The siRNA included in the double helix oligo-RNA structure specifically acts on the serotype of all dengue viruses. In addition, the present invention relates to a method for preparing the double helix oligo-RNA structure, and a pharmaceutical composition containing the double helix oligo-RNA structure for preventing or treating a dengue virus infection. |
priorityDate |
2013-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |