Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78587acbfc8d4c9e9ac3baa7021087d7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-179 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1774 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 |
filingDate |
2014-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0914380546e1ac58bdcee68503cb77e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d2fd97cf4aafbedbb49b01d7019b70f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04e25037bec7185ef45eff53c5683e21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dd41b0efd51e9938d21c05f23945e9a |
publicationDate |
2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2909701-C |
titleOfInvention |
Immunosuppressive tgf-.beta. signal converter |
abstract |
Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGFß receptor including the exodomain of a TGFßII receptor and an endodomain that is not from TGFß receptor, thereby converting the negative signal of TGFß for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGFß receptor also harbor one or more chimeric antigen receptors. |
priorityDate |
2013-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |