| abstract |
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S) -1- (2-hydroxyethyl) -4-methyl-N- [4- (methylsulfonyl) pheny 1] -5- [2- (trifluoromethyl) phenyl] -1H-pyrrole-3-carboxamide . (See Formula I) |