| abstract |
Provided herein are variant human lgG1 Fe molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells. IL-2 binds three transmembrane receptor subunits: IL-2R- and IL-2Rywhich together activate intracellular signaling events upon IL-2 binding, and CD25 (IL-2Ra) which serves to stabilize the interaction between IL-2 and IL-2RBY.The signals delivered by IL-2RBYinclude those of the PI3-kinase, Ras-MAP-kinase, and STAT5 pathways. |