| abstract |
The present invention relates to the compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R1, R2, R3, R4, R5, R6, X1 and X2 are further described herein. These compounds are protein kinases inhibitors, especially the inhibitors of Mek, which are useful in the treatment of cancers and inflammation of mammals. The invention also relates to the treatment methods of cancers and inflammation of mammals as well as pharmaceutical compositions comprising the compounds described herein. The present invention also concerns the preparation of benzoheterocyclic compounds. The invention mainly relates to the preparation of potential drug candidates, such as benzooxazol, benzothiazol, benzothiadiazol and the like. (see formula I) |