| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc4469cd1df8dd56462903c5f56a88b3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-04 |
| filingDate |
2012-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9b53615aefa9d5d613d9307a3cdc877
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5e48fe4a66682e031589795cb1c5e86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc966c286646e5e90e71372cf545b18 |
| publicationDate |
2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2886544-C |
| titleOfInvention |
Treatment of pulmonary surfactant dysfunction using cholesterol-sequestering cyclodextrins |
| abstract |
The use of cholesterol-sequestering agents, such as methyl-beta-cyclodextrin, for the treatment of pulmonary surfactant dysfunction is disclosed. It was discovered that oxidative damage to pulmonary surfactant arises due to the interaction between reactive oxygen species and cholesterol. Thus, by removing cholesterol from pulmonary7 surfactant through the addition of a cholesterol-sequestering agent, oxidative damage to the surfactant is mitigated. It was also shown that methyl-beta-cyclodextrin can restore normal function to dysfunctional surfactant removed from the lungs of children with cystic fibrosis and non cystic fibrosis bronchiolitis. |
| priorityDate |
2012-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |