| abstract |
The present disclosure describes a biosensor, comprising: a substrate comprising one or more elongated shanks for penetrating biological tissue, and a microfabricated electrode array proximate the distal end of one or more of the elongated shanks, wherein the array comprises one or more recording sites; and at least one aptamer affixed to one or more of the recording sites, wherein the at least one aptarner is selected to selectively react with one or more chemical compounds. Methods of using the biosensor are also described. |