| abstract |
ABSTRACT The invention provides compounds and compositions useful for the modulation of certain enzymes. One such compound may be a compound of Formula I: R.I'N 0 14:70 ( Njr$1,14 I R2) n H (I) wherein R1 is an optionally substituted benzoyl; n is 1, 2, 3, or 4; and each R2 is independently H, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, carboxy, halo, amino, alkylamino, dialkylamino, trifluoromethyl, trifluoromethoxy, benzyl, benzyloxy, nitro, cyano (-CN), sulfonamide (-SO2NH2), acetylene, N-alkyl-triazole, or N-benzyl-triazole; or two R2 groups form an ortho-fused benzo group;or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells. |