| abstract |
The present invention relates to a method for preventing the formation of rotigotine crystals. More particularly, the present invention relates to a method for preventing the precipitation of rotigotine crystals, comprising a step of mixing rotigotine and one or more crystallization prevention agents selected from the group consisting of fatty alcohols, fatty acids, fatty acid esters, fatty acid amides, and the derivatives thereof, and to a transdermally absorbable preparation that comprises rotigotine and crystallization prevention agents. The method and system of the present invention enable the prevention of the precipitation of rotigotine to thus increase stability during long-term storage, and therefore can be effectively applied to the manufacture of rotigotine-containing patches or the like. |