| abstract |
The present invention relates to pharmacologically active isochroman and isothiochroman derivatives, or pharmaceutically acceptable salts thereof, as well as to pharmaceutical compositions comprising them and to their use as alpha2 adrenoceptor agonists, especially as alpha2A agonists, such as for the treatment of delirium, hyperactive delirium, insomnia, ADHD, benzodiazepine or alcohol or opioid or tobacco withdrawal, premature ejaculation, hypertension, tachycardia, restless leg syndrome, muscular spasticity, hot flashes, anxiety, post traumatic stress disorder, pain, chronic pelvic pain syndrome, breakthrough cancer pain, or a condition wherein sedation or analgesia is needed. |