| abstract |
The present invention provides intranasal formulations for use in treating pain in a human adult by intranasal administration of about 35 lig, about 40 lig or about 50 lig of dexmedetomidine, or a pharmaceutically acceptable salt thereof. The present invention also provides use of a pharmaceutical composition comprising dexmedetomidine, or a pharmaceutically acceptable salt thereof, for treating pain in a human adult in need thereof, the pharmaceutical composition is formulated for intranasal administration to a single nostril at a dose of about 35 lig, about 40 lig, about 45 lig, about 50 lig, about 55 lig, or about 60 pg vvhereby the use produces a Cpbs.a of about 0.1 ng/ml within about 15 minutes to about 20 minutes of the use and has an analgesic effect during the hour immediately after the use, wherein the human adult is cooperative, oriented, and tranquil during the hour immediately after the use. |