| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fdb573bf5f4eacd6c6c95919889feb8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00822
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00094
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00894
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-0059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00873
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00099
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-0086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00011 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0093
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J8-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate |
2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e71dad609e889167921741249306f8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd80e3853921ec603630ee9f3ffc534c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e6ab671cdd4a276faa4a7b06fb49d0d |
| publicationDate |
2013-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2847858-A1 |
| titleOfInvention |
Methods and systems for forming boronic acids and intermediates thereof |
| abstract |
Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a l-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The l-chloro-2-substituted-3 -fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed. |
| priorityDate |
2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |