| abstract |
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl] amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate having the structure, (see structure) and pharmaceutically acceptable salts and solvates thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. |