| abstract |
The disclosure relates to antibodies that bind FcRn and methods of using these antibodies. Optionally, an isolated antibody that binds human neonatal Fc receptor (FcRn), comprising a light chain variable region (VL) and a heavy chain variable region (VH), wherein: the VL comprises: (a) a VL CDR1 comprising the amino acid sequence of TGTGSDVGSYNLVS (SEQ ID NO: 14), (b) a VL CDR2 comprising the amino acid sequence of GDSQRPS (SEQ ID NO: 15), and (c) a VL CDR3 comprising the arnino acid sequence of SSYAGSGIYV (SEQ ID NO: 12) or ASYAGSGIYV (SEQ ID NO: 13); and the VH comprises: (a) a VH CDR1 comprising the amino acid sequence of EYAMG (SEQ ID NO:22); (b) the VH CDR2 comprising the amino acid sequence of SIGSSGGQTKYADSVKG (SEQ ID NO:23); and (c) the VH CDR3 comprising the amino acid sequence of LAIGDSY (SEQ ID NO:24). |