| abstract |
The purpose of the present invention is to provide a novel drug useful as a therapeutic or prophylactic agent for cachexia which is a systemic syndrome involving, as the main symptoms, a remarkable body weight loss, anemia, edema, anorexia, general prostration, a feeling of weariness and so on in chronic diseases such as malignant tumor, tuberculosis, diabetes, blood diseases, endocrine diseases, infections, acquired immune deficiency syndrome, etc. The present invention provides a therapeutic or prophylactic agent for cachexia comprising, as the active ingredient, a compound having a specific morphinan skeleton, a typical example of which is a compound having a structure represented by chemical formula (1), or a pharmacologically acceptable acid addition salt thereof. |