| abstract |
Novel therapeutic agents for myeloma are provided. A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): (see formula 1) wherein R1 is C1 -C6 alkyl, C1 -C6 alkyl substituted with R17, C1 -C6 haloalkyl, phenyl, phenyl substituted with a R11' s or the like, R2 is a hydrogen atom, C1 -C6 alkyl, phenyl or phenyl optionally substituted with e R21' s or the like, R3 is a hydrogen atom or the like, X is a single bond or -(CR6 R7 )n -, each of R4 and R5 is independently C1 -C6 alkyl or the like, R6 and R7 are hydrogen atoms or C1 -C6 alkyl, R8 is phenyl, phenyl optionally substituted with k R81's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient. |