| abstract |
Provided is an antibody, which binds to the subtype EP4 of human PGE2 receptor and inhibits the function of EP4, or a functional fragment thereof. Also provided is a drug comprising said antibody or a functional fragment thereof. Mice were immunized with the subtype EP4 of human PGE2 receptor and a monoclonal antibody suppressing an increase in intracellular cAMP due to EP4 was screened. The CDR sequence of the monoclonal antibody thus obtained was determined. |