Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058e0be30e00d53858c67167df60aed5 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-962 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
filingDate |
2011-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b26c637500428368f9897ddc8cd95537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46977fa85ce38f563b76a08a7a342275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75a5da98f76acfecddbd5845004da2ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f491084acf985f5b5cd1fa20a8d7f0ca |
publicationDate |
2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2811107-A1 |
titleOfInvention |
Prolyl endopeptidase probes |
abstract |
Prolyl endopeptidase (PE) activity in lung samples is detected by contacting the lung sample with a probe comprising a -P-X- (or -X-P-, -P-X-P-) PE recognition site, wherein P is a prolyl bioisostere, X is a residue that is not a prolyl bioisostere or is a prolyl bioisostere flanked on each side by a residue that is not a prolyl bioisostere, and "-" is an amide bond, under conditions wherein PE activity of the sample specifically hydrolyzes an amide bond of the recognition site to generate an optical signal; and (b) detecting the signal. |
priorityDate |
2010-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |