http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2793151-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_078dac059a34bbd78c474e44fc6e8a57 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2011-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c73010a232a031309d3322ed953e4b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7b4771074ce20a9affd95a224af5692 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b632a06608a1079788e75a5f66345f20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50fe4c4cd7723abded07cc5fc5ed095b |
| publicationDate | 2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2793151-A1 |
| titleOfInvention | In vitro process for the quick determination of a patient's status relating to infection with mycobacterium tuberculosis |
| abstract | An in-vitro process for the quick determination of the infection status of a Mycobacterium tuberculosis infection from whole blood in terms of active or latent tuberculosis, comprising the steps of: stimulating an antigen-specific T cell that is present in a first sam¬ ple of whole blood with purified protein derivative (PPD) in the presence of antibodies against CD28, or CD28 and CD49d; processing of PPD by antigen-presenting cells (APC) by incubating for 1.5 h to 2.5 h, especially for 2 h, at 35 °C to 39 °C, especially at 37 °C, optionally with adding C02; then adding a secretion inhibitor; effecting an intensive mixing; and another incubation for a period of at least 2.5 h at a temperature of from 35 °C to 39 °C, and determining a cytokine profile from both the intracellular INF-? production and the intracellular IL-2 production of the antigen-specific T cell; wherein the presence of an active tuberculosis is indicated by a shift of the cytokine profile towards IFN-? single positive cells accompanied by a decrease of IFN-y/IL-2 double positive T cells. |
| priorityDate | 2010-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.