| abstract |
The subject of the present invention is the compounds of Formula (I) in which: R represents a hydrogen or halogen atom or a (C1-C6) alkyl group; X represents one or more substituents chosen from a hydrogen or halogen atom, a group (C1 - C6) alkyl, halogen (C1 - C6) alkyl, (C1 - C6) alkoxy, halogen (C1 - C6) ) alkoxy, cyano, hydroxy or hydroxy (C1-C6) alkyl, Y represents a hydrogen atom, halogen or a group (C 1 -C 6) alkyl; RI is NR2R3 or OR4; R2 and R3 represent, independently from each other, a hydrogen atom, a (C 1 -C 6) alkyl, hydroxy group (C1-C6) alkyl or oxo (C1-C6) alkyl, or R2 and R3 form with the nitrogen atom that carries them a heterocycle optionally substituted with a (C1-C6) alkyl, hydroxy or oxo group, R4 represents a group (C1-C6) alkyl, hydroxy (C1-C6) alkyl or oxo (C1-C6) alkyl, in the form of base or salt of addition to an acid The compounds of formula (I) are used in therapeutic in treatment or the prevention of diseases involving Nurr-1 nuclear receptors, also called NR4A2, NOT, TINUR, RNR-1, and HZF3. |