| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate |
2005-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b353e57f75375da52bc4e9fe99348f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc8f87d526c3e7eeb0a5f09f64e48df5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_302d9feb2fc8840bb1ef36528415b889
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2160683a685e0016f910b6cf1d37135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9cc00a8d75fac400cc6697576a961f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77bb4eac547a9ea554302544d53d9ed1 |
| publicationDate |
2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2777216-A1 |
| titleOfInvention |
Process for preparing atazanavir bisulfate and novel forms |
| abstract |
A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate wherein a solution of atazanavir free base is reacted with concentrated sulfuric acid in an amount to react with less than about 15% by weight of the free base, seeds of Form A crystals of atazanavir bisulfate are added to the reaction mixture, and as crystals of the bisulfate form, additional concentrated sulfuric acid is added in multiple stages at increasing rates according to a cubic equation, to effect formation of Form A crystals of atazanavir bisulfate. A process is also provided for preparing atazanavir bisulfate as Pattern C material. A novel form of atazanavir bisulfate is also provided which is Form E3 which is a highly crystalline triethanolate solvate of the bisulfate salt from ethanol. |
| priorityDate |
2004-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |