| abstract |
The present invention describes IL-1ß binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1ß. Binding proteins of the invention have high affinity for IL-1ß and neutralize IL-1ß activity. A binding protein of the invention can be a full-length antibody or an IL-1ß -binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1ß binding proteins of the invention are useful for detecting IL-1ß and for inhibiting IL-1ß activity, including in a human subject suffering from a disease or disorder in which IL-1ß activity is detrimental. |