http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2774614-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c727d0aef5b1f28290f7ccdf941d6ead |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J23-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2010-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_908ccc3eec3b94c944a3649a9c750085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7064e4752db24cdf7dec656eda6362a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79fd1a22693bd8f7a608671e649c7796 |
| publicationDate | 2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2774614-C |
| titleOfInvention | Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof |
| abstract | The present invention is an improved method for the preparation of 4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester, compound of formula I. The invention is directed to a method of synthesis for the compound of formula I in three steps, comprising formation of 5-((tert-butoxycarbonyl)aminomethyl)-2-fluorobenzeneboronic acid (compound 11), reaction of compound 11 under Suzuki coupling conditions to yield (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester and selective hydrogenation of the aforementioned product under hydrogenation conditions yields compound I. The invention is also directed to the intermediates 5-((tert-Butoxycarbonyl)amino-methyl)-2-fluorobenzeneboronic acid (compound 11), and (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester (compound 13). |
| priorityDate | 2009-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.