| abstract |
Substituted hydrazide compounds shown by general formula I and application thereof are disclosed. The substituted hydrazide compounds include geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrug thereof, wherein substituents Ar and R have meanings presented in the specification. Also the application of the compounds of general formula I in the preparation of medicines for treating and/or preventing cancer and other proliferative diseases is disclosed. |