abstract |
The present invention relates to compounds of chemical formula 1, which exhibit antagonistic effects against chemokine receptor 2 (CCR2), and to salts or isomers thereof. The compounds are useful in treating, preventing, or improving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma and other CCR2-related diseases. R1, R2, R3, R4, R5, R6, R7, R8 and R9 in chemical formula 1 are identical to those expressed in the present specification. |