abstract |
A composition for treatment of or prevention of fatigue, comprising an effective amount of a compound of Formula I: (see formula I) or a pharmaceutically acceptable salt or ester thereof, wherein Rx is selected from one of hydrogen, C1-8 alkyl, F, CI, Br, I, C1-3 alkoxy, nitro, hydroxy, trifluoromethyl, and C1-3 thioalkoxy; x is an integer of 1-3, wherein R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different and are independently selected from one of hydrogen, C1-8 alkyl, aryl, heteroaryl, arylalkyl, and C1-3 cycloalkyl; or R1 and R2 can be joined to form a 5-7-membered heterocycle substituted with one of hydrogen, alkyl, aryl, and heteroaryl groups, wherein the cyclic compound comprises 1-2 nitrogen atoms and 0-1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom. |