http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2762911-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7307b233757226bbd4ecfb3fceee4f4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f11bb967a062874458385247870694a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2eb691263b6037930f6faf8f2e71cca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
| filingDate | 2007-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_626e0dbda92f24b60fbd5450eb5c06fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e836e6db01ed032f625d89bb4d3eadb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c377d2d8f65c2f8a9c13c78ef991e191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d794e49f032ffdc5a33c176dba7460b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_090b6807d083013c377f8e4c588b32a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a08213dbc144bc3d9e020da50f537de2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c7f38ca02991bf376611c233aa584e4 |
| publicationDate | 2008-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2762911-A1 |
| titleOfInvention | Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation |
| abstract | The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic functional group is derivatized on this functional group with a substituent selected from the group comprising quarternary ammonium substituents of general formula X b bound to the carboxy group of the terpenoid, wherein X b is -- (CH2)n N+R3Y-, quarternary ammonium substituents of general formula X c bound to the carboxy group of the terpenoid, wherein X c je -(CH2)nR+Y-, glycosylic substituents X e bound by .alpha. or .beta. glycosidic bond to the carboxy group of the terpenoid, wherein X e is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lacyosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetra-cyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. |
| priorityDate | 2006-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.