| abstract |
The subject of the invention is a method for detoxifying lipopolysaccharide (LPS) or lipid A of a bacterium Gram-negative according to which LPS or lipid A is mixed with a lipid canonically and optionally, a co-lipid, for to form a complex in which LPS or lipid A is associated with lipid cationic. According to modes of preparation cationic lipid with co-lipid, if the latter is present, is structured into complexes, inter alia into liposomes. In the preparation of lipid complexes, the addition of LPS or lipid A leads to the association of the latter with cationic lipid, an association in which LPS or lipid A is found substantially detoxified. LPS or Lipid A detoxified in this form can then be used as vaccine antigen or as an adjuvant. |